Research Papers

# Denotes equal contribution           * Corresponding author

2019

65. John G,* Nagarajan S, Silverman J, Vemula PK, Pillai CKS.* “Natural monomers: A mine for functional and sustainable materials – Occurrence, chemical modification and polymerization” Prog. Polym. Sci. 2019, in press. 

64. Singh R, Chandrashekharappa S, Bodduluri SR, Baby BV, Hegde B, Kotla NG, Hiwale AA, Saiyed T, Patel P, Vijay Kumar M, Langille MGI, Douglas GM, Cheng X, Rouchka EC, Waigel SJ, Dryden GW, Alatassi H, Zhang HG, Haribabu B, Vemula PK*, Jala VR*, "Enhancement of gut barrier integrity by a microbial metabolite through the Nrf2 pathway" Nat. Commun. 2019, 10, 89. Link

[Press/media coverage: The HinduBiomeBuzzScience ChronicleGENEurekAlert,  Medicalxpress & many more. ]

63. Jain A, Dhiman S, Dhayani A, Vemula PK,* Subi G.* "Chemical fuel-driven living and transient supramolecular polymerization" Nat. Commun. 2019, 10, 450. Link


62. C Anton Fries, Lawson SD, Wang LC, Slaughter KV, Vemula PK, Dhayani A, Joshi N, Karp JM, Rickard RF, Gorantla VS, Davis MR. "Graft-implanted, enzyme responsive, tacrolimus-eluting hydrogel enables long-term survival of orthotopic porcine limb vascularized composite allografts: A proof of concept study" PLoS ONE 2019, 14(1): e0210914. Link

2018

61. Thorat K, Pandey S, Chandrashekharappa S, Vavilthota N, Hiwale AA, Shah P, Sreekumar S, Upadhyay S, Phuntsok T, Mahato M, Mudnakudu-Nagaraju KK, Sunnapu O, Vemula PK.* “Prevention of pesticide-induced neuronal dysfunction and mortality with nucleophilic poly-Oxime topical gel” Sci. Adv. 20184, eaau1780. Link

[Press/media coverage: Science podcastC&ENThe HinduThe Hindu national, ScienceDailyHindustanTimesTechnologyNetworks & more]

60. Rangasami VK, Lochania B, Voshavar C, Rachamalla HR, Banerjee R, Dhayani A, Thangavel S, Vemula PK,* Marepally S.* “Exploring membrane permeability of Tomatidine to enhance lipid mediated nucleic acid transfections” BBA Biomembranes 20191861, 327-334. Link

59. Totiger TM, Srinivasan S, Jala VR, Lamicchane P, Dosch AR, Gaidarski-III AA, Joshi C, Rangappa S, Castellanos J, Vemula PK, Chen X, Kwon D, Kashikar N, VanSaun M, Merchant NB, Nagathihalli S.* “Urolithin A, a natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer” Mol. Cancer Ther. 2018, Nov 7. pii: molcanther.0464.2018 Link

58. Dzhonova D, Olariu R, Leckenby J, Dhayani A, Vemula PK, Prost J-C, Banz Y, Taddeo A,* Reiben R.* “Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging” PloS ONE, 201813, e0203409. Link 

57. Kotla NG,* Rana S, Sivaraman G, Sunnapu O, Vemula PK, Pandit A, Rochev Y.* “Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives” Adv. Drug Deliv. Rev. 2018doi.org/10.1016/j.addr.2018.06.021 ​​​​​​​ Link

56. Dzhonova D, Olariu R, Leckenby J, Banz Y, Prost J-C, Dhayani A, Vemula PK, Voegelin E, Taddeo A.* Rieben R.* “Local injections of tacrolimus-loaded hydrogel reduce systemic immunesuppression-related toxicity in vascularized composite allotransplantation” Transplantation 2018, 102, 1684.  Link

55. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter K, Sherman NE, Amirault J, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Aliprantis A, Ermann J,* Karp JM.* “Towards an arthritis flare-responsive drug delivery system” Nat. Commun. 20189, 1275. Link

2017

54. Sasidharan V,# Marepally S,# Eliott SA, Baid S, Lakshmanan V, Nayyar N, Bansal D, Sanchez-Alvarado A, Vemula PK,* Palakodeti D.* “The miR-124 family of microRNAs critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea” Development 2017144, 3211-3223.Link

[Press/media coverage:  PharmabizGubbi LabsBiostandupsinStem & more]

53. Gergovska M, Briand E, Karp JM, Jacob SE, Vemula P, Gospodinov D, Kazandjieva J. “Metal sequestering dermal cream exhibits beneficial effects in patients with dyshidrotic eczema associated with nickel induced allergic contact dermatitis - a pilot study” Allergy 201772, 310. Link

52. Singh R, Hegde B, Baby BV, Sandeep C, Kotla N, Chandrasekar B, Marepally S, Bodduluri H, Vemula PK, Jala VR. “Targeted delivery of microbial metabolite, urolithin A protects from chemically (DSS or TNBS) induced colitis in pre-clinical models” J. Immunol 2017198 (1 Supplement), 65-6. Link

51. Hiwale AA, Voshavar C, Dharmalingam P, Dhayani A, Muktavaram R, Nadella R, Sunnapu O, Gandhi S, Naidu VGM, Chaudhuri A, Marepally S,* Vemula PK.* “Scaling the effect of hydrophobic chain length on gene transfer properties of di-alkyl, di-hydroxy ethylammonium chloride based cationic amphiphiles” RSC Adv. 2017, 7, 25398-405. Link

50. Lalitha K, Sridharan V, Maheswari CU, Vemula PK, Nagarajan S.* “Morphology transition in the helical tubules of supramolecular gel driven by metal ions” Chem. Commun. 201753, 1538-41. Link

49. Puroshothaman G, Juvale K, Kirubakaran S, Vemula PK, Thiruvenkatam V.* “Structural studies of 1,2-O-cyclohexylidene-myo-inositol: Insights of hydrogen bonding interactions” Acta Crysts. C 2017C73, 20-27. Link 

2016

48. Kurbet AS, Hegde S, Bhattacharjee O, Marepally S, Vemula PK, Raghavan S*. “Sterile inflammation enhances ECM degradation in integrin β1 KO embryonic skin” Cell Reports 201616, 3334-47. Link

[Press/media coverage: The Times of IndiaPharmabizIndian Science JournalBiostandupsinStem& more]

47. Divya KP, Miroshnikov M, Dutta D, Vemula PK,* Ajayan PM, John G.* “In situ synthesis of metal nanoparticle embedded hybrid soft nanomaterials” Acc. Chem. Res. 201649, 1671-1680. (An invited review) Link

46. Vemula PK, Jala VR.* “Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells” Transl. Cancer Res. 2016, doi: 10.21037/tcr.2016.08.24 (An invited commentary) Link

45. Meka RR, Godeshala S, Marepally S, Thorat K, Rachamalla HKR, Dhayani A, Hiwale AA, Banerjee R, Chaudhuri A, Vemula PK.*  “Asymmetric cationic lipids based non-viral vectors for an efficient nucleic acid delivery.” RSC Adv. 2016, 6, 77841-48. Link

44. Wu K, Dhayani A, Slaughter K, Karp JM, Joshi N, Vemula P, Wang L, Cindass R, Lawson S, Gorantla VS, Davis MR. “Graft-implanted tacrolimus-eluting hydrogels prolong survival after vascularized composite allotransplantation” Bri. J. Surgery 2016103, 92.

43. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim D-H, Kim J-S, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev, A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla M-E, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T.  “Voices of Biotech.” Nat. Biotechnol. 201634, 270-275. (Feature) Link

42. Saha P, Yeoh BS, Singh R, Chandrasekar B, Vemula PK, Haribabu B, Vijay-Kumar M.* Jala VR.*  “Gut mitochondria conversion of dietary ellagic acid into bioactive phytoceutical urolithin A inhibits heme peroxidases.” PLoS ONE 2016, 1(6): e0156811. Link

41. Mathiyazhakan M, Upputuri PK, Sivasubramanian K, Dhayani A, Vemula PK, Zou P, Pu K, Yang C, Pramanik M, Xu C.* "In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging". Sci. China Mater. 2016, 59, 892-900. Link

40. Selot R, Marepally S, Vemula PK, Jayandharan GR*. Nanoparticle coated viral vectors for gene therapy. Curr. Biotechnol. 20165, 44-53. Link 

2015

39. Zhang S,# Ermann J,# Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G,* Langer R,* Karp JM.*  “An inflammation-targeting hydrogel for local delivery in inflammatory bowl disease”. Sci. Transl. Med. 20157, 300ra128. (#Denotes equal contribution) Link

38. Sen D, Vemula PK, Jayandharan GR. “Intra-articular gene transfer of miR-15b attenuates molecular mediators of hemophilic arthropathy in a murine model of hemophilia”. Mol. Therapy 201523, S96-S97.

37. Lalitha K, Muthusamy K, Prasad YS, Vemula PK, Nagarajan S.* "Recent developments in beta-C-glycosides: Synthesis and applications". Carbohydrate Res. 2015, 402, 158-171. Link

2014

36. Gajanayake T,# Olariu R,# Leclere FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM,* Vemula PK,* Rieben R,* Vogelin E. “A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft”. Sci. Transl. Med. 2014, 6, 249ra110. (#Denotes equal contribution) Link

[Press/media coverage: The HinduDeccan HeraldPharmabizHealthcanal Health NewsHarvard News & more]

35. Vemula PK,# Kohler JE,# Blass A, Williams M, Xu C, Chen L, Jadhav SR, John G, Soybel DI,* Karp JM.* “Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu”. Sci. Rep. 20144, 4466; DOI:10.1038/srep04466 (#Denotes equal contribution) Link

34. Periera MN, Lang N, Masiakos P, Sundback C, Ouyang B, Cho W, Vemula PK, Langer R,* Ferreira N,* Karp JM.*“Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation”. Adv. Healthcare Mater. 20143, 565-571. Link

2013

33. Vemula PK,* Wiradharma N, Ankrum JA, Miranda OR, John G, Karp JM.* “Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials”. Curr. Opin. Biotechnol. 201324, 1174-1182. Link (Invited review)

32. Balachandran VS, Jadhav SR, Vemula PK,* John G.* “Recent advances in cardanol chemistry in a nutshell: from a nut to nanomaterials”. Chem. Soc. Rev. 201342, 427-438. (Cover Feature) Link (Invited review)

31. Gajanayake T,* Olariu R, Leclere F, Vemula PK, Yang Z, Bongoni A, Banz Y, Constantinescu M, Vogelin E, Rieben R. "Complement activation in vascularized composite allotransplantation". Mol. Immunol. 201356, 283.

30. Vemula P, Levy O, Valic M, Sanchez OM, Anand P, Aliprantis AO, Karp JM.* "On-demand drug delivery from self-assembled hydrogels: a new approach for treatment of inflammatory arthritis". Ann. Rheum. Dis. 2013, 72, A817.

2012

29. Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM.* “Tracking mesenchymal stem cells with iron oxide nanoparticles loaded poly(lactide-co-glycolide) microparticles”. Nano Lett. 201212, 4131-4139. Link

2011

28. Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM.* “Engineered cell homing”. Blood 2011118, e184-e191. Link

27. Vemula PK, Anderson RR, Karp JM.* “Animal models for nickel allergy”. Nat. Nanotechnol. 20116, 533. [Correspondence] Link

26. Vemula PK, Anderson RR, Karp JM.* “Nanoparticles reduce nickel allergy by capturing metal ions”. Nat. Nanotechnol. 20116, 291-295. Link
 

[Press/media coverage: CNNLos Angeles TimesScienceDailyNanowerk, Harvard News & more]

25. Vemula PK#, Boilard E#, Syed A, Campbell NR, Muluneh M, Weitz DA, Lee DM, Karp JM.* “On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease”. J. Biomed. Mater. Res. A 2011,97A, 103-110. (#denotes equal contribution) Link    
 

[Press/media coverage: The Times of IndiaScience DailyAlatimes, Harvard News]

24. Mitsouras D,* Vemula PK, Yu P, Tao M, Nyugen BT, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. “Immobilized Contrast Enhanced (ICE) MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall”. Magn. Reson. Med. 201165, 176-183. (Cover Feature) Link

2010

23. Nguyen BT#, Vemula PK#, Mitsouras D, Yu P, Tao M, Campagna C, Mulkern RV, Rybicki FJ, Karp JM,* Ozaki CK.*“Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging - An ex vivo feasibility study”. Bioconjugate Chem. 201021, 1408-1412. (#denotes equal contribution) Link

22. Jadhav SR, Vemula PK, Kumar R, Raghavan SR, John G.* “Sugar derived phase-selective molecular gelators as model oil spills and solidifiers”. Angew. Chem. Int. Ed. 201049, 7695-7698. (Cover Feature) Link    
 

[Press/media coverage: Discovery NewsNature Chemistrymsnbc.com news, Chemical & Engineering News, Science Daily, Nanowerk, TCE Today & more]

21. Sarkar D, Vemula PK, Zhao W, Gupta A, Karnik R, Karp JM.* “Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting”. Biomaterials 201031, 5266-5274. Link

20. Ozaki CK,* Mitsouras D, Vemula PK, Smiley D, Tao M, Yu P, Campagna C, Zhao W, Mulkern RV, Karp J, Rybicki F. “Novel implantable vein graft contrast yields enhanced outer wall definition in magnetic resonance imaging”. J. Vasc. Surgery 2010, 51, 533. Link

19. John G,* Shankar BV, Jadhav SR, Vemula PK. "Biorefinery: A design tool for molecular gelators". Langmuir 201026, 17843-17853. (Cover Feature) Link 
 

[Press/media coverage: The New York Times]

2009

18. Vemula PK#, Cruikshank GA#, Karp JM,* John G.* “Self-assembled prodrugs: an enzymatically triggered drug delivery platform”. Biomaterials 200930, 383-393. (#denotes equal contribution) Link

17. Jyothish K, Vemula PK, Jadhav SR, Francesconi LC, John G.* “Self-standing, metal nanoparticle embedded transparent films from multi-armed cardanol conjugates through in situ synthesis”. Chem. Commun. 2009, 5368-5370. (Cover Feature)Link

2008

16. Sarkar D, Vemula PK, Teo GSL, Spelke D, Karnik R, Wee YL, Karp JM.* “Chemical engineering of mesenchymal stem cells to induce a cell rolling response”. Bioconjugate Chem. 200819, 2105-2109. Link

15. Kumar A#, Vemula PK#, Ajayan PM, John G.* “Silver-nanoparticle-embedded anti-microbial paints based on vegetable oil” Nat. Mater. 20087, 236-241. (#denotes equal contribution) Link
 

[Press/media coverage: Nature NanotechnologyScientific AmericanChemical & Engineering News, MRS Webnews, Biomaterials Today, Materials Today, United Press International (UPI) & more]

14. Vemula PK, Douglas K, Achong C, Kumar A, Ajayan PM, John G.* “Autoxidation induced metal nanoparticles synthesis in biobased polymeric systems: A sustainable approach in hybrid materials development”. J. Biobased Mater. Bioenergy 20082, 218-222. (Cover Feature) Link

13. Vemula PK, John G.* “Crops: a green approach toward self-assembled soft materials”. Acc. Chem. Res. 200841, 769-782.Link

2007

12. Mallia, VA#, Vemula PK#, John G,* Kumar A, Ajayan PM.* “In situ synthesis and assembly of gold nanoparticles embedded glass forming liquid crystals” Angew. Chem. Int. Ed. 200746, 3269-3274. (#denotes equal contribution) Link
 

[Press/media coverage: Materials Research Society highlights, ‘Materials 360’ as image in Focus, Nanowerk, World Gold Council & more]

11. Vemula PK#, Mallia VA#, Bizati K, John G.* “Cholesterol phenoxy hexanoate mesogens: Effect of meta substituents on their liquid crystalline behavior and in situ metal nanoparticle synthesis” Chem. Mater. 200719, 5203-5206. (#denotes equal contribution) Link

10. Vemula PK, Aslam U, Mallia VA, John G.* “In situ synthesis of gold nanoparticles using molecular gels and liquid crystals from vitamin-C amphiphiles” Chem. Mater. 200719, 138-140. Link

2006

9. Vemula PK, Li J, John G.* “Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs” J. Am. Chem. Soc. 2006128, 8932-8938. Link
 

[Press/media coverage: Nanowerk, Green Chemistry Network, Chemical Science, Chemistry World, NYSTAR News, ACS-Heart Cut, Materials Today, National Science Foundation (NSF), Food USA, In-Pharma Technologist.com, Green Chemistry (RSC) & more]

8. Vemula PK, John G.* “Smart amphiphiles: hydro/organogelators for in situ reduction of gold” Chem. Commun. 2006, 2218-2220. (Cover Feature) Link 
 

[Press/media coverage: Chemical & Engineering News, Top TEN articles in May2006, NYSTAR nanotech, CUNY News & more]

7. John G,* Vemula PK.”Design and development of soft nanomaterials from biobased amphiphiles” Soft Matter 20062¸ 909-914. (Cover Feature) [Was selected as Best Cover page of the year-2006 from RSC] Link
 

[Press/media coverage: Nature 2007, 445, 5, Newsweek, Decade of Science-CUNY Matters & more]

2005-2002

6. Bhattacharya S,* Vemula PK. “Effect of heteroatom insertion at the side chain of 5-alkyl-1H-tetrazoles on their properties as catalysts for ester hydrolysis at neutral pH” J. Org. Chem. 200570, 9677-9985. Link

5. Bhattacharya S,* Kumar VP. "Ester cleavage properties of synthetic hydroxybenzotriazoles in cationic monovalent and gemini surfactant micelles” Langmuir 200521, 71-78. Link

4. Kumar VP, Ganguly B,* Bhattacharya S.* “Computational study on hydroxybenzotriazoles as reagents for ester hydrolysis” J. Org. Chem. 200469, 8634-8642. Link

3. Bhattacharya S,* Kumar VP. “Evidence of enhanced reactivity of DAAP nucleophile toward dephosphorylation and deacylation reactions in cationic gemini micellar media” J. Org. Chem. 200469, 559-562. Link

2. Bhattacharya S,* Snehalatha K, Kumar VP. “Synthesis of new Cu (II)-chelating ligand amphiphiles and their esterolytic properties in cationic micelles” J. Org. Chem. 200368, 2741-2747. Link

1. Subramanian S, Kumar VP, Bhattacharya S.* “Synthesis of phospholipids with fatty acid chains containing aromatic units at various depths” ARKIVOC 2002VII, 116-125. Link