Patents


We have seventeen (16) issued or pending patents or technology disclosures, a number of which have been licensed by biotech companies.


Book Chapters/Abstracts


4. Mahato M, Sherman NE, Mudnakudu NKK, Joshi N, Briand E, Karp JM,* Vemula PK.* Book Chapter “Preventaion of metal exposure: Chelating agents and barriers”. In: Metal allergy, Springer Nature, 2017.

3. Wang M, Marepally SK, Vemula PK,* Xu C.* Book Chapter “Inorganic nanoparticles for transdermal drug delivery and topical application”. In: Nanoscience and Dermatology, Elsevier, 2016.

2. Dutta D, Marepally SK, Vemula PK.* Book Chapter “Noncovalent Functionalization of Cell Surface”. In:  Micro- and Nanoengineering of the Cell Surface,  Elsevier, 2014.

1. Vemula PK, Campbell NR, Zhao F, Xu B, John G, Karp JM.* Book Chapter “Self-assembled prodrugs”. In: Ducheyne P, Healy KE, Hutmacher DW, Grainger DW, Kirkpatrick CJ (eds.) Comprehensive Biomaterials, vol. 4, pp. 339-355 Elsevier, 2011. Link

- 17 Abstracts.


Publications


# Denotes equal contribution           * Corresponding author


2017

53. Sasidharan V,# Marepally S,# Eliott SA, Baid S, Lakshmanan V, Nayyar N, Bansal D, Sanchez-Alvarado A, Vemula PK,* Palakodeti D.* “The miR-124 family of microRNAs critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea” Development 2017, 144, 3211-3223. Link

52. Gergovska M, Briand E, Karp JM, Jacob SE, Vemula P, Gospodinov D, Kazandjieva J. “Metal sequestering dermal cream exhibits beneficial effects in patients with dyshidrotic eczema associated with nickel induced allergic contact dermatitis - a pilot study” Allergy 2017, 72, 310. Link

51. Hiwale AA, Voshavar C, Dharmalingam P, Dhayani A, Muktavaram R, Nadella R, Sunnapu O, Gandhi S, Naidu VGM, Chaudhuri A, Marepally S,* Vemula PK.* “Scaling the effect of hydrophobic chain length on gene transfer properties of di-alkyl, di-hydroxy ethylammonium chloride based cationic amphiphiles” RSC Adv. 2017, 7, 25398-405. Link

50. Lalitha K, Sridharan V, Maheswari CU, Vemula PK, Nagarajan S.* “Morphology transition in the helical tubules of supramolecular gel driven by metal ions” Chem. Commun. 2017, 53, 1538-41. Link

49. Puroshothaman G, Juvale K, Kirubakaran S, Vemula PK, Thiruvenkatam V.* “Structural studies of 1,2-O-cyclohexylidene-myo-inositol: Insights of hydrogen bonding interactions” Acta Crysts. C 2017, C73, 20-27. Link


2016

48. Kurbet AS, Hegde S, Bhattacharjee O, Marepally S, Vemula PK, Raghavan S*. “Sterile inflammation enhances ECM degradation in integrin β1 KO embryonic skin” Cell Reports 2016, 16, 3334-47. Link

[Press/media coverage: The Times of India, Pharmabiz, Indian Science Journal, Biostandups, inStem & more]

47. Divya KP, Miroshnikov M, Dutta D, Vemula PK,* Ajayan PM, John G.* “In situ synthesis of metal nanoparticle embedded hybrid soft nanomaterials” Acc. Chem. Res. 2016, 49, 1671-1680. (An invited review) Link

46. Vemula PK, Jala VR.* “Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells” Transl. Cancer Res. 2016, doi: 10.21037/tcr.2016.08.24 (An invited commentary) Link

45. Meka RR, Godeshala S, Marepally S, Thorat K, Rachamalla HKR, Dhayani A, Hiwale AA, Banerjee R, Chaudhuri A, Vemula PK.*  “Asymmetric cationic lipids based non-viral vectors for an efficient nucleic acid delivery.” RSC Adv. 2016, 6, 77841-48. Link

44. Wu K, Dhayani A, Slaughter K, Karp JM, Joshi N, Vemula P, Wang L, Cindass R, Lawson S, Gorantla VS, Davis MR. “Graft-implanted tacrolimus-eluting hydrogels prolong survival after vascularized composite allotransplantation” Bri. J. Surgery 2016, 103, 92.

43. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim D-H, Kim J-S, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev, A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla M-E, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T.  “Voices of Biotech.” Nature Biotechnol. 2016, 34, 270-275. (Feature) Link

42. Saha P, Yeoh BS, Singh R, Chandrasekar B, Vemula PK, Haribabu B, Vijay-Kumar M.* Jala VR.*  “Gut mitochondria conversion of dietary ellagic acid into bioactive phytoceutical urolithin A inhibits heme peroxidases.” PLoS ONE 2016, 1(6): e0156811. Link

41. Mathiyazhakan M, Upputuri PK, Sivasubramanian K, Dhayani A, Vemula PK, Zou P, Pu K, Yang C, Pramanik M, Xu C.* "In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging". Sci. China Mater. 2016, 59, 892-900. Link

40. Selot R, Marepally S, Vemula PK, Jayandharan GR*. Nanoparticle coated viral vectors for gene therapy. Curr Biotechnol. 2016, 5, 44-53. Link


2015

39. Zhang S,# Ermann J,# Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G,* Langer R,* Karp JM.*  “An inflammation-targeting hydrogel for local delivery in inflammatory bowl disease”. Science Transl. Med. 2015,  7, 300ra128. (#Denotes equal contribution) Link

38. Sen D, Vemula PK, Jayandharan GR. “Intra-articular gene transfer of miR-15b attenuates molecular mediators of hemophilic arthropathy in a murine model of hemophilia”. Mol. Therapy 2015, 23, S96-S97.

37. Lalitha K, Muthusamy K, Prasad YS, Vemula PK, Nagarajan S.* “Recent developments in β-C-glycosides: Synthesis and applications”. Carbohydrate Res. 2015, 402, 158-171. Link


2014

36. Gajanayake T,# Olariu R,# Leclere FM, Dhayani A, Yang Z, Bongoni AK, Banz Y, Constantinescu MA, Karp JM,* Vemula PK,* Rieben R,* Vogelin E. “A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft”. Science Transl. Med. 2014, 6, 249ra110. (#Denotes equal contribution) Link

[Press/media coverage: The Hindu, Deccan Herald, Pharmabiz, Healthcanal Health News, Harvard News & more]

35. Vemula PK,# Kohler JE,# Blass A, Williams M, Xu C, Chen L, Jadhav SR, John G, Soybel DI,* Karp JM.* “Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu”. Sci. Rep. 2014, 4, 4466; DOI:10.1038/srep04466 (#Denotes equal contribution) Link

34. Periera MN, Lang N, Masiakos P, Sundback C, Ouyang B, Cho W, Vemula PK, Langer R,* Ferreira N,* Karp JM.* “Combined surface micropatterning and reactive chemistry maximizes tissue adhesion with minimal inflammation”. Adv. Healthcare Mater. 2014, 3, 565-571. Link


2013


33. Vemula PK,* Wiradharma N, Ankrum JA, Miranda OR, John G, Karp JM.* “Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials”. Curr. Opin. Biotechnol. 2013, 24, 1174-1182. Link (Invited review)


32. Balachandran VS, Jadhav SR, Vemula PK,* John G.* “Recent advances in cardanol chemistry in a nutshell: from a nut to nanomaterials”. Chem. Soc. Rev. 2013, 42, 427-438. (Cover Feature) Link (Invited review)

31. Gajanayake T,* Olariu R, Leclere F, Vemula PK, Yang Z, Bongoni A, Banz Y, Constantinescu M, Vogelin E, Rieben R. "Complement activation in vascularized composite allotransplantation". Mol. Immunol. 2013, 56, 283.

30. Vemula P, Levy O, Valic M, Sanchez OM, Anand P, Aliprantis AO, Karp JM.* "On-demand drug delivery from self-assembled hydrogels: a new approach for treatment of inflammatory arthritis". Ann. Rheum. Dis. 2013, 72, A817.


2012



29. Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM.* “Tracking mesenchymal stem cells with iron oxide nanoparticles loaded poly(lactide-co-glycolide) microparticles”. Nano Lett. 2012, 12, 4131-4139. Link


2011

28. Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, Kumar S, Karnik R, Lin CP, Karp JM.* “Engineered cell homing”. Blood 2011, 118, e184-e191. Link

27. Vemula PK, Anderson RR, Karp JM.* “Animal models for nickel allergy”. Nature Nanotechol. 2011, 6, 533. [Correspondence] Link

26. Vemula PK, Anderson RR, Karp JM.* “Nanoparticles reduce nickel allergy by capturing metal ions”. Nature Nanotechnol. 2011, 6, 291-295. Link
[Press/media coverage: CNN, Los Angeles Times, ScienceDaily, Nanowerk, Harvard News & more]

25. Vemula PK#, Boilard E#, Syed A, Campbell NR, Muluneh M, Weitz DA, Lee DM, Karp JM.* “On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease”. J. Biomed. Mater. Res. A 2011, 97A, 103-110. (#denotes equal contribution) Link   
[Press/media coverage: The Times of India, Science Daily, Alatimes, Harvard News]

24. Mitsouras D,* Vemula PK, Yu P, Tao M, Nyugen BT, Karp JM, Mulkern RV, Ozaki CK, Rybicki FJ. “Immobilized Contrast Enhanced (ICE) MRI: Gadolinium-based long-term MR contrast enhancement of the vein graft vessel wall”. Magn. Reson. Med. 2011, 65, 176-183. (Cover Feature) Link


2010

23. Nguyen BT#, Vemula PK#, Mitsouras D, Yu P, Tao M, Campagna C, Mulkern RV, Rybicki FJ, Karp JM,* Ozaki CK.* “Immobilization of iron oxide magnetic nanoparticles for enhancement of vessel wall magnetic resonance imaging - An ex vivo feasibility study”. Bioconjugate Chem. 2010, 21, 1408-1412. (#denotes equal contribution) Link

22. Jadhav SR, Vemula PK, Kumar R, Raghavan SR, John G.* “Sugar derived phase-selective molecular gelators as model oil spills and solidifiers”. Angew. Chem. Int. Ed. 2010, 49, 7695-7698. (Cover Feature) Link   
[Press/media coverage: Discovery News, Nature Chemistry, msnbc.com news, Chemical & Engineering News, Science Daily, Nanowerk, TCE Today & more]

21. Sarkar D, Vemula PK, Zhao W, Gupta A, Karnik R, Karp JM.* “Engineered mesenchymal stem cells with self-assembled vesicles for systemic cell targeting”. Biomaterials 2010, 31, 5266-5274. Link

20. Ozaki CK,* Mitsouras D, Vemula PK, Smiley D, Tao M, Yu P, Campagna C, Zhao W, Mulkern RV, Karp J, Rybicki F. “Novel implantable vein graft contrast yields enhanced outer wall definition in magnetic resonance imaging”. J. Vasc. Surgery 2010, 51, 533. Link

19. John G,* Shankar BV, Jadhav SR, Vemula PK. "Biorefinery: A design tool for molecular gelators". Langmuir 2010, 26, 17843-17853. (Cover Feature) Link
[Press/media coverage: The New York Times]


2009


18. Vemula PK#, Cruikshank GA#, Karp JM,* John G.* “Self-assembled prodrugs: an enzymatically triggered drug delivery platform”. Biomaterials 2009, 30, 383-393. (#denotes equal contribution) Link

17. Jyothish K, Vemula PK, Jadhav SR, Francesconi LC, John G.* “Self-standing, metal nanoparticle embedded transparent films from multi-armed cardanol conjugates through in situ synthesis”. Chem. Commun. 2009, 5368-5370. (Cover Feature) Link



2008


16. Sarkar D, Vemula PK, Teo GSL, Spelke D, Karnik R, Wee YL, Karp JM.* “Chemical engineering of mesenchymal stem cells to induce a cell rolling response”. Bioconjugate Chem. 2008, 19, 2105-2109. Link

15. Kumar A#, Vemula PK#, Ajayan PM, John G.* “Silver-nanoparticle-embedded anti-microbial paints based on vegetable oil” Nature Mater. 2008, 7, 236-241. (#denotes equal contribution) Link
[Press/media coverage: Nature Nanotechnology, Scientific American, Chemical & Engineering News, MRS Webnews, Biomaterials Today, Materials Today, United Press International (UPI) & more]

14. Vemula PK, Douglas K, Achong C, Kumar A, Ajayan PM, John G.* “Autoxidation induced metal nanoparticles synthesis in biobased polymeric systems: A sustainable approach in hybrid materials development”. J. Biobased Mater. Bioenergy 2008, 2, 218-222. (Cover Feature) Link

13. Vemula PK, John G.* “Crops: a green approach toward self-assembled soft materials”. Acc. Chem. Res. 2008, 41, 769-782. Link


2007


12. Mallia, VA#, Vemula PK#, John G,* Kumar A, Ajayan PM.* “In situ synthesis and assembly of gold nanoparticles embedded glass forming liquid crystals” Angew. Chem. Int. Ed. 2007, 46, 3269-3274. (#denotes equal contribution) Link
[Press/media coverage: Materials Research Society highlights, ‘Materials 360’ as image in Focus, Nanowerk, World Gold Council & more]

11. Vemula PK#, Mallia VA#, Bizati K, John G.* “Cholesterol phenoxy hexanoate mesogens: Effect of meta substituents on their liquid crystalline behavior and in situ metal nanoparticle synthesis” Chem. Mater. 2007, 19, 5203-5206. (#denotes equal contribution) Link

10. Vemula PK, Aslam U, Mallia VA, John G.* “In situ synthesis of gold nanoparticles using molecular gels and liquid crystals from vitamin-C amphiphiles” Chem. Mater. 2007, 19, 138-140. Link


2006


9. Vemula PK, Li J, John G.* “Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs” J. Am. Chem. Soc. 2006, 128, 8932-8938. Link
[Press/media coverage: Nanowerk, Green Chemistry Network, Chemical Science, Chemistry World, NYSTAR News, ACS-Heart Cut, Materials Today, National Science Foundation (NSF), Food USA, In-Pharma Technologist.com, Green Chemistry (RSC) & more]

8. Vemula PK, John G.* “Smart amphiphiles: hydro/organogelators for in situ reduction of gold” Chem. Commun. 2006, 2218-2220. (Cover Feature) Link
[Press/media coverage: Chemical & Engineering News, Top TEN articles in May2006, NYSTAR nanotech, CUNY News & more]

7. John G,* Vemula PK.”Design and development of soft nanomaterials from biobased amphiphiles” Soft Matter 2006, 2¸ 909-914. (Cover Feature) [Was selected as Best Cover page of the year-2006 from RSC] Link
[Press/media coverage: Nature 2007, 445, 5, Newsweek, Decade of Science-CUNY Matters & more]

2005-2002


6. Bhattacharya S,* Vemula PK. “Effect of heteroatom insertion at the side chain of 5-alkyl-1H-tetrazoles on their properties as catalysts for ester hydrolysis at neutral pH” J. Org. Chem. 2005, 70, 9677-9985. Link

5. Bhattacharya S,* Kumar VP.”Ester cleavage properties of synthetic hydroxybenzotriazoles in cationic monovalent and gemini surfactant micelles” Langmuir 2005, 21, 71-78. Link

4. Kumar VP, Ganguly B,* Bhattacharya S.* “Computational study on hydroxybenzotriazoles as reagents for ester hydrolysis” J. Org. Chem. 2004, 69, 8634-8642. Link

3. Bhattacharya S,* Kumar VP. “Evidence of enhanced reactivity of DAAP nucleophile toward dephosphorylation and deacylation reactions in cationic gemini micellar media” J. Org. Chem. 2004, 69, 559-562. Link

2. Bhattacharya S,* Snehalatha K, Kumar VP. “Synthesis of new Cu (II)-chelating ligand amphiphiles and their esterolytic properties in cationic micelles” J. Org. Chem. 2003, 68, 2741-2747. Link

1. Subramanian S, Kumar VP, Bhattacharya S.* “Synthesis of phospholipids with fatty acid chains containing aromatic units at various depths” ARKIVOC 2002, VII, 116-125. Link



Cover Gallery




  
   Sci China Mater 2016



   
   Chem Soc Rev 2013



    
     MRM 2011



     
      ACIE 2010
 


     
      Langmuir 2010



     
      Chem.Commun. 2009




     
      JBMB 2008




     
      Soft Matter 2006

     


     
      Chem. Commun. 2006



     
    Soft Matter Award 2006